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   The human retina promises to be a window into the health of a patient. A clear view of the retina in vivo with high-resolution detail of photoreceptors and vascular flow gives the vital details that enable clinicians to make early and accurate diagnoses of diseases. This window is blurred, however, by imperfections in the eye itself: the cornea and crystalline lens, as well as the viscous and non-uniform nature of the vitreous humor, prevent clinicians from viewing the important cellular structures.  Adaptive optics solves this problem by correcting for these imperfections at a microscopic level and allows for high-resolution imaging of photoreceptor cells.

confocal SLO using deformable mirrors adaptive optics technology

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Fig. 1

Adaptive Optics Scanning Laser Ophthalmoscope (AOSLO) imaging functions have been quantified by Dr. Jennifer Sun, MD, MPH and her team at Beetham Eye Institute, Joslin Diabetes Center and Dr. Amani Fawzi at the Feinberg School of Medicine at Northwestern University for use in pre-clinical and clinical studies. Our Apaeros™ Retinal Imaging System has enabled measures of cone physiology, detection of microaneurysms, small-vessel blood flow measurement, and offset aperture imaging capabilities through its cutting edge adaptive optics design. Unlike systems operating without adaptive optics, Apaeros can achieve a lateral resolution of ~2.3 µm, enabling in vivo high-resolution imaging necessary for vision scientists.

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By actively correcting for wavefront aberrations in the optical path between the imaging camera and the retina, adaptive optics has emerged as an enabling technology for retinal imaging with cellular-level resolution.

This technology holds promise for non-invasive detection and diagnoses of leading eye pathologies such as glaucoma, diabetic retinopathy, and age related macular degeneration (AMD).

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Adaptive optics technology today enables retinal imaging that can achieve better than 2 µm resolution, producing detailed images of photoreceptor cells, as seen in Figure 1.

This image was created using a 140 actuator Multi‑DM.

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APAEROS Retinal Imaging System

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 Retinal Imaging