More information can be found in the following works:


Structural Characteristics of Microaneurysms on AOSLO and Surrounding Neural Retinal Pathology in Diabetes

JK Sun, PS Silva, SA Burns, LP Aiello,Joslin Diabetes Center, Department of Ophthalmology, Harvard Medical School
Presented at ARVO 2013


Microaneurysm Lumen Clot

Instrument Functions: Detection of Microaneurysms

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Microaneurysm wall reflectivity
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The following microaneurysm attributes can be measured:

- Dimension
- Presence of lumen clot
- Wall Reflectivity

Images © 2012 Beetham Eye Institute, Joslin Diabetes Center. All rights reserved. Courtesy JK Sun, MD, MPH

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​​​
 Apaeros offers the capability to identify micro aneurysms (MA) which are undetectable by other retinal imaging modalities. The user can examine vascular retinal planes in vivo with cell-scale resolution. This may enable researchers to explore retinal pathology developments, effects on visual acuity and response to treatment. 


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From the listed capabilities above, Apaeros has enabled various investigative studies. The results of these studies have shown:

- MA wall hyper-reflectivity on AOSLO images is significantly associated with larger MA size and the presence of retinal inner layer disorganization

- The presence of a MA lumen clot correlates with larger MA size, but not with neural retinal changes on Spectral Domain Optical Coherence Tomography (SDOCT)

- For MA’s located within 500 µm of the foveal center, the presence of wall hyper reflectivity is associated with worse VA, even after adjusting for MA size or inner layer disorganization²

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