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Instrument Functions: Quantitative Measures of Cone Physiology

Kilo-DM Mirror Mount
   Cone Physiology
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   Offset Aperture Imaging
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The Apaeros Retinal Imaging System generates images that allows the user to identify individual photoreceptors. Through third party software, Apaeros enables the user to measure various properties of retinal cone physiology. Through its enhanced imaging capabilities, the following attributes can be evaluated:

  • Cone Density
  • Nearest Neighbor Distance
  • Voronoi Tessellation Tile Area
  • Effective Radius
  • Packing Factor

Since Apaeros can image these attributes, the system has enabled various investigative studies, specifically:

  • Increasing severity of Diabetic Retinopathy associated with decrease in cone regularity
  • Diabetic Macular Edema associated with cone mosaic changes, cone reflectance  and decreased regularity of cone spacing

Video © 2012 Beetham Eye Institute, Joslin Diabetes Center. All Rights Reserved. Courtesy JK Sun, MD, MPH

More information can be found in the following works:
Changes in Cone Density, Reflectivity and Regularity  Assessed by AOSLO In Diabetic Retinopathy
J Lammer, A Ahmed, S Prager, M Cheney, SA Burns, PS Silva, LP Aiello, JK Sun, Beetham Eye Institute, Joslin Diabetes Center
Presented at ARVO 2013

Imaging of Vascular Wall Fine Structure in Human Retina using Adaptive Optics Scanning Laser Ophthalmoscopy
T Chui, T Gast, S Burns

List of all related works

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